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Diabetes Obes Metab (2020) 22(10):172941
PMID: 21209017
Inhibition of DPP-IV elevates endogenous GLP concentrations, but DPP-IV also independently modulates inflammatory mediators, including stromal cell-derived factor 1 (SDF-1) and regulated upon activation, normal T cell expressed and presumably secreted (RANTES) (7981)
This restriction underscores the agencys concern regarding unknown clinical safety, product purity, and long-term toxicity profiles in human use
For GLP-1 users whose top question is what reduced appetite is costing them nutritionally, nothing on this list goes deeper
The upper intake limit for calcium is 2,000-2,500 mg daily (age-dependent), with excessive supplementation potentially associated with cardiovascular and kidney stone risks
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